How to diagnose and treat acute viral hepatitis

Joel Lavine
4 min readJun 8, 2022

Acute viral hepatitis is a common liver illness that is caused by a virus. How to treat the condition depends on what caused it. Hepatitis A and E often cause acute hepatitis, which gets better on its own with IV fluids and medicine to stop nausea. Patients should be instructed not to share personal objects, to avoid sexual activity, and to use condoms. Women should not have sex while they are on their period. The disease is very contagious, and people who have it need to know that they could pass it on to others.

Joel Lavine remarked that as the disease progresses, the levels of serum bilirubin, alanine aminotransferase (ALT), and hepatic enzymes tend to rise, but their absolute values don’t show how bad the disease is. Patients with acute viral hepatitis have high levels of bilirubin in their urine, which is usually accompanied by jaundice. Some people who get cholestasis also have high levels of alkaline phosphatase and ALT. Rarely is a liver biopsy needed to make a sure diagnosis, but it may be done to rule out drug-induced or toxic hepatitis.

If a person is thought to have acute viral hepatitis, blood tests should be done to rule out other diseases. If you use a lancet to poke a hole in your skin, it will bleed. Blood is taken from a person and put in a test tube, on a slide, or on a strip. A bandage can be put on the wound to stop the bleeding. The sample of blood is then sent to a lab for more tests. Blood tests can find hepatitis virus antibodies. If there are no antibodies, the diagnosis is said to be negative.

Joel Lavine observed that the HEV genome has 1693 codons and a protein called the open reading frame (ORF) that codes for structural proteins in the viral capsid. The virus is found in almost every country in the world, and some areas are more likely to get it than others. Vaccines are effective against HEV. After being exposed, symptoms of infection can show up within days or weeks. If a person has an infection that hasn’t been diagnosed, treatment is meant to ease the symptoms and stop the disease from spreading.

Several things will affect how much an acute viral hepatitis panel will cost. Acute viral hepatitis panels test for both hepatitis A and hepatitis B, as well as chronic hepatitis. Chronic hepatitis can last for years, which scars the liver and makes it fail in the end. If your acute viral hepatitis panel comes back positive, you will usually need to get more tests.

Even though HBV usually doesn’t cause long-term illness, it can cause cholestatic hepatitis or even cirrhosis. But the virus goes away in the vast majority of people who get it, and this is shown by an increase in IgG anti-HEV times. About 60% of people with acute HEV also have cholestasis that lasts for a long time. In most cases, symptoms include itching, feeling sick, and pain in the joints.

The hepatitis A virus is what causes hepatitis A. The virus spreads through contaminated food and water. People get the virus when they touch feces that has the virus or when they eat or drink blood or body fluids that have the virus. In underdeveloped countries, there are often epidemics, and young people are usually the ones who get hepatitis A. Even sexual contact can spread the disease from one person to another.

HAV or HBV, the most common type, is what causes acute viral hepatitis. HAV is the least common type to be diagnosed, but if you don’t treat it, it can lead to chronic hepatitis. Even though all three viruses can cause liver disease, the symptoms and results are different for each one. So, treatment should be based on what caused the disease in the first place. Acute viral hepatitis can’t be cured in a certain way.

Depending on what caused it, the symptoms of acute viral hepatitis can be different. People can get acute viral hepatitis by touching blood that is already sick. They can also give the disease to other people if they share needles. Vaccination programs have cut the risk of infection after a transfusion by a huge amount. Another big risk factor is sexually transmitted diseases. The disease can cause the liver to stop working and scar up.

Joel Lavine pointed out that acute viral hepatitis happens most often in countries with few resources. Acute HBV cases are steadily going down, with the exception of a single outbreak in the US that was caused by food. But a recent rise in cases is mostly caused by people who use drugs and people who are homeless. Since the vaccine came out in 1990, the number of people getting acute HBV infections has gone down by a lot. Most people who get acute viral hepatitis are older and have high-risk habits like using injection drugs, having more than one sexual partner, and not getting vaccinated before.

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Joel Lavine

Joel Lavine MD has had a lengthy career filled with several highlights that demonstrate his abilities and significance in his area.